In terms of aesthetic treatments, injectables like Botox, Dysport, and Xeomin, as well as dermal fillers, are the gold standard for smoothing the appearance of fine lines and wrinkles. If you aren’t ready for an in-office treatment or are looking for a less intrusive technique, we have some good news for you. While nothing beats injectibles, there are numerous skincare products that fill fine lines and relax wrinkles for smoother, bouncy skin.
These aptly dubbed “Botox in a bottle” skincare solutions, according to Dr. Michele Green, a NYC-based board-certified cosmetic dermatologist, blur small lines and wrinkles, resulting in firmer, smoother skin with an impact similar to Botox injections. “They contain chemicals like peptides, matrixyl, and retinol [a vitamin A derivative], which work to stimulate collagen and elastin formation while also boosting cellular turnover to revitalise your skin,” explains Dr. Green.
These wrinkle-reducing serums and creams may not work immediately, but with continued usage, they can reduce the appearance of fine lines. With the assistance of Dr. Green, we’ve compiled a list of the 5 finest wrinkle-relaxing serums, creams, and targeted treatments to smooth out fine lines and minimise the appearance of wrinkles—no needles required.
Celergen Switzerland Serum Royale

This Swiss-based company’s anti-aging treatment combats ageing in a variety of methods. To begin, the solution works to increase your skin’s natural collagen production by combining potent antioxidants and peptides that noticeably firm, tighten, and enhance suppleness. The Bio DNA marine cell included within the lighting fluid also aids your skin’s barrier in combating environmental stressors such as UV rays and pollution, which are primary causes of premature ageing. It also helps to balance out skin tone by minimising the appearance of dark spots and discolouration for a fresh, vibrant complexion.
The Ordinary Argireline Solution 10%

Remove wrinkles with the TikTok-famous serum that sparked the viral “Botox in a bottle” skincare sensation. Argireline is the commercial name for the peptide acetyl hexapeptide-3, which is a fragment of the SNAP-25 protein, which is also used in Botox. “Argireline inhibits the production of a neurotransmitter called catecholamine, which induces muscle contraction,” explains Dr. Green. It does not penetrate the skin as deeply as Botox, but it does promote collagen formation and increase collagen function, which improves skin hydration and reduces the appearance of creases and wrinkles. Furthermore, according to Green, its alcohol-free and oil-free recipe is water-based, which maximises the efficiency of Argireline.
Heraux Molecular Anti-Inflammaging Serum

Do you have inflammation yet also wish to remove lines and wrinkles? This potent serum is for you. It contains line-reducing peptides as well as HX-1, a substance that serves as a defender against stress molecules and protects stem cells from the detrimental effects of oxidative stress and inflammation. There’s also an anti-aging cocktail with vitamin C, E, and hyaluronic acid that leaves skin smooth, plump, and firm.
Erasa Xep 30 Extreme Line Lifting and Rejuvenation Concentrate

This display-worthy bottle contains a potent serum-meets-moisturizer that is tough on fine lines and wrinkles. The flagship ingredient, XEP 30, a neuropeptide comparable to Botox, softens skin and smoothes out wrinkles, providing softened skin and smoother-looking lines. Furthermore, niacinamide, squalane, and sodium hyaluronate moisturise, plump, and enhance skin texture. Within two weeks of constant application, you’ll see a reduction in fine lines and wrinkles. Linda Evangelista, a 1990s supermodel, swears by this substance.
Olay Regenerist Collagen Peptide 24 Moisturizer

Another of Green’s recommendations, this drugstore selection competes with the more expensive serums and lotions on this list. This lightweight, fragrance-free lotion with collagen and peptides plumps and smoothes skin over time. Green also mentions glycerin and niacinamide, which moisturise and improve skin texture.